Process of treating frothy bloat in ruminants and tympanic colic in horses



Patented Apr. 21, 1953 PROCESS TREATING FROTHY BLOAT IN RUMINANTS AND TYMPANIC COLIC 1N HORSES James A. Austin and Karl A. Ratclifl, Mission,

Kans., assignors to Jensen-Salsbery Labora- 3 tories,'Inc., Kansas City, Mo., a corporation of .Missouri No Drawing. Application March 23, 1949, Serial No. 83,100

3 Claims.

This invention relates to improvements in the treatment of frothy bloat in the ruminants cattle, sheep and goats and the ailment variously known as tympanic colic, gastric distension or gastric tympanitis in horses. 5 injected directly into the rumen, has shown an Heretofore frothy bloat and tympanic colic effectiveness of about 90%. have been treated only with difliculty, and while e Organic silicones Which are used in the medicaments have been available which are P a e O th invention e the polymerized sometimes effective, it has been frequently necesy ea bon silicones 0f the general ul sary to use surgical means to relieve the distress. R

In accordance with the present invention, frothy bloat in ruminants and tympanic colic in horses is relieved and effectively treated by the R1 I administration of an organic silicone or silicate in which R. and R1 represent hydrocarbon groups, either by injection directly into the rumen or by usually but not necessarily alike, which may oral administration, e. g, as a drench, the silicone range from C1 (methyl) to C8 (octyl) or may be or silicate being administered in a form in which alicyclic (e. g., cyclohexyl) or aryl (e. g., phenyl) t is d y pers d 0r usp d d th ughout or aralkyl (e. g., benzyl). In general, compounds an aqueous medium. Administration of the silii whi h the groups R and R1 are lower alkyl cone or silicate in a hydrophobe solvent, for exgroups (amyl or lower) are most valuable. The a p in oetyl alcohol or in oil or oil-like solvents, organic silicates used are the corresponding prodis not nearly as effective in relieving the frothy nets in which the hydrocarbon groups are linked b t 0r y p li p rh ps b aus it preto the silicon through oxygen, instead of being vents the release of the silicone or silicate and directly linked to the silicon, i. e., of the formula its distribution throughout the food mass. In general, it is advantageous to administer the material in a form in which it is readily dispersed throughout the food mass, for example, in aque- R10 ous suspension using a dispersing agent to form mmethyl Silicone polymer has been Shown to be a suitable suspension or dispersion, or in the form particularly effeotive Those organic silicones of a tablet in which the silicone is adsorbed on and silicates are W611 known materials and the carrier, such as kieselguhr, starch or the like, sol-notion of their production is therefore unneoeswhich may then be Crushed 111 Water and glven sary. Satisfactory methyl silicones are available as a drench. An aqueous suspension of the main the open market Thickening agents, such as t rial, f r x l obtained by emulsifying or colloidal silica, may be included in the silicone suspending it in water with a suspending or discomposition if desired, persing agent such as triethanolamine oleate may Thus a ilicone h h We have found highly be adm n d by injection, using one Of the effective is a high molecular weight methyl siliusual syri es d needles and injecting directly cone thickened with a non crystalline form of into the rumen or caecum 01' as a drenehsilica in the colloidal state. One such product We have found that with cat l gram of is available on the market under the trade name an organic silicone administered either hypoof D C Antifoam A, sold by The Dow Corning dermically in the form of a triethanolamine Company. It was this product which was used oleate aqueous suspension or as a dren h, as y in the clinical tests referred to above, with adcru hin nd p n n i w r a tablet havministration of 1.0 gram, either in the form of ing the silicone adsorbed on kieselguhr and using the aqueous suspension using triethanolamine starch, milk sugar and gelloid, granulating and oleate as the suspending or dispersing agent, or compressing on a tablet machine in the usual in the form of a tablet which was crushed in way, has shown about 80% effectiveness without water and administered as a drench. the use of any surgical procedures, in marked con- The following are typically useful products trast to the treatments which have heretofore embodying the invention: been available for the treatment of this afiliction. Example I.8 pounds of powdered milk sugar, It is possible that some of the failures in this 3 pounds of starch, 1 pound of kieselguhr, 500 clinical work resulted from administration in grams of high molecular weight dimethyl silsuch a way as to introduce the silicone into the icone (D C Antifoam'A),-l-pint of ether (solvent 2 true stomach rather than into the rumen, and that if proper administration had been obtained in all cases, the level of effectiveness would have been even higher. A suspensionof the silicone,

for the silicone), 10 grains of oil soluble yellow color, 4 ounces of gelloid and 1 gallon of starch paste are admixed, passed through a #16 screen and drieche ounces of talcum, 12 ounces of starch, 1 ounce of octyl alcohol and 120 min. of oil of peppermint are added and the mixture compressed into tablets, each containing 0.5 gram of V the silicone.

Example II .-80 grams of oleic "acid are warmed slightly and added to 20 grams of triethanol amine and the mixture stirred until a smooth, homogeneous paste is obtained. high molecular weight dimethyl silicone and 2 cc. of oil of peppermint are stirred .in and water to make 1000 cc. is then slowly added, with stirring until an even suspension is obtained.

We claim:

1. The process of treating frothy bloat in ruminants and tympanic colic in horses which comprises introducing into the frothy food mass responsible for distress a material of the class consisting of organic silicones and organic sili'cates.

'2. process of treating frothy bloat in ruminants and tympanic colic in horses which comprises introducing into the frothy food mass responsible for distress an organic silicone.

10 grams of 2 4 3. The process as in claim 2 in which the organic silicone is a high molecular weight methyl silicone.

7 JAMES A. AUSTIN.

KARL A; RATCLIFF.

References Cited in the file of this patent UNITED STATES PATENTS Numb P Name Date 2,375,007 Larsen May 1, 1945 2,443,067 Burns June 8, 1948 2,512,192 Yen .1 June 20, 1950 OTHER REFERENCES RoweJournal of Industrial Hygiene and Toxicology. November 1948, pages 332 to 352.

I-lutyraPathology and Therapeutics of the Diseases of Domestic Animals, volume 2 (1938), pages 72 to 76.

Pearson Diseases of the Horse (1916). page 73.

Dow Corning Silicone Note 13001: September 1948), page 30.

Shepherd-Washingt0n Post, December 24, 1951, page 5B. 

1. THE PROCESS OF TREATING FROTHY BLOAT IN RUMINANTS AND TYMPANIC COLIC IN HORSES WHICH COMPRISES INTRODUCING INTO THE FROTHY FOOD MASS RESPONSIBLE FOR DISTRESS A MATERIAL OF THE CLASS CONSISTING OF ORGANIC SILICONES AND ORGANIC SILICATES. 